You need the logic levels configured digirig: Digirig Mobile – digirig
See this post for cables: Cable for Anytone AT-D578UV III Pro & Plus
You can make/buy the audio-only cable for RTS PTT, or at the bottom of the post there’s an audio/serial cable that you can make that will support CAT PTT. I’m working with Hamlib to get the Anytone added to the library, it’s been added to VARA FM, and SoundModem. There’s more info about compatible software here: Home · jrobertfisher/AT-D578UV-software-mic Wiki · GitHub